Increased resting energy expenditure compared with predictive theoretical equations in amyotrophic lateral sclerosis

Approximately 50% to 60% of amyotrophic lateral sclerosis (ALS) is characterized by an increase in metabolic rate. The Harris and Benedict (HB) 1919 formula is the equation mainly used to calculate resting energy expenditure (cREE) compared with measured REE (mREE) by indirect calorimetry (IC), but other formulas are also applied in current practice.

The present study aimed to assess mREE in patients with ALS compared with 12 cREE formulas and study the relevant threshold of REE variation to screen patients with a higher evolving risk.Nutritional assessments and body composition (by bioimpedance analysis) were performed in patients with ALS.

mREE was measured by IC, and cREE was calculated using the HB 1919, HB 1984, World Schofield, De Lorenzo, Johnstone, Mifflin, World Health Organization/FoodandAgricultureOrganization, Owen, Fleisch, Wang, Rosenbaum, and Nelson formulas.

Functional and respiratory evolution and survival by log-rank test according to two thresholds of REE variation (10% and 20%) were studied.A total of 315 patients with ALS were included in the study. The median mREE was 1503 kcal/24 h (range, 1290-1698 kcal/24 h), which was higher than all predictive equations (P < 0.0001). Depending on the predictive equation, REE variation >10% and 20% was found in 35.2% to 76.3% and 14.6% to 53.3% of patients with ALS, respectively.

Patients with an REE variation >20% with HB 1919 and HB 1984 had a lower survival. Moreover, with this same threshold and the Mifflin formula, patients had higher functional and respiratory evolutions and lower survival.The increase in metabolic rate is present according to the different cREE formulas used compared with IC.

In clinical practice, REE formulas (e.g., HB 1919, HB 1984, or Mifflin) can be used as a reference value compared with IC to screen patients with ALS with an REE variation >20% and a higher evolving risk.

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462472 25.0mg
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(R)-FL-118

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Description: 151636-76-9

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FL118

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FL118

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FL-411

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Human IL-37 (1F7/F1L1zeta) ELISA Kit

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Gilson PIPETMAN L Fixed F5000L 5000ul - EACH

FA10031 EACH
EUR 288.9

ORF1 FL49 (CYSTM1) (NM_032412) Human Over-expression Lysate

LS084418 100ug
EUR 628
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[Tyr10]-F2L (1-21) / [Tyr10]-HBP (1-21) (Rat, Mouse)

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Description: 50337-85-4

3-(3-Fluorobenzyl)-4-[(3-fluorobenzyl)oxy]benzaldehyde

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1-(4-Fluorophenyl)-N-[(4-fluorophenyl)methyl]methanimine

F632245 250mg
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5-Fluoro-2-(4-fluorophenyl)-4-(trifluoromethyl)-1,3-oxazole

F601165 100mg
EUR 1200
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(S)-2-[[3-(3-Fluorobenzyl)-4-[(3-fluorobenzyl)oxy]benzyl]amino]propanamide

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EUR 775
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F428220 500mg
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5-fluoro 203

C4114-10 10 mg
EUR 154
Description: AhR signaling activator

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4-fluoro-N-(3-fluoro-4-methylphenyl)-3-{[(4-methoxyphenyl)methyl

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FG-G-072-34A 100 μl
EUR 666.36

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F587245 10mg
EUR 158
Description: 1971007-89-2

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H-072-30 100 μl
EUR 666.36

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T-G-072-34 10 μCi
EUR 1145.88

5-fluoro AMT HCl

463460 1.0mg
EUR 350

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F588720 10mg
EUR 759
Description: 1445580-60-8

pCDNA3.1-FLAG(-)

PVT18203 2ug
EUR 162

(4-Fluoro-1-naphthalenyl)[1-(5-fluoropentyl)-1H-indol-3-yl]methanone

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EUR 1800
Description: 1391485-39-4

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5-Fluoro-AMB

F587305 100mg
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F01640 5G
EUR 106.51

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EUR 461.7

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EUR 157.6

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EUR 604.6

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EUR 208.5

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EUR 439.5

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EUR 150.1

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MBS5778987-5mg 5(mg
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MBS440075-02mg 0.2mg
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One Health refers to the collaborative efforts of multiple disciplines working locally, nationally and globally to attain optimal health for people, animals and our environment.

The One Health approach is increasingly popular in the context of growing threats from emerging zoonoses, antimicrobial resistance and climate change.

The Food and Agriculture Organization of the United Nations, World Organisation for Animal Health and World Health Organization have been working together in the wake of the avian influenza crisis in the Asia-Pacific region to provide strong leadership to endorse the One Health concept and promote interagency and intersectoral collaboration.

The programme on highly pathogenic emerging diseases in Asia (2009-2014) led to the establishment of a regional tripartite coordination mechanism in the Asia-Pacific region to support collaboration between the animal and human health sectors. The remit of this mechanism has expanded to include other priority One Health challenges, such as antimicrobial resistance and food safety.

The mechanism has helped to organize eight Asia-Pacific workshops on multisectoral collaboration for the prevention and control of zoonoses since 2010, facilitating advocacy and operationalization of One Health at regional and country levels.

The tripartite group and international partners have developed several One Health tools, which are useful for operationalization of One Health at the country level. Member States are encouraged to develop a One Health strategic framework taking into account the country’s context and priorities.