Increased resting energy expenditure compared with predictive theoretical equations in amyotrophic lateral sclerosis

Approximately 50% to 60% of amyotrophic lateral sclerosis (ALS) is characterized by an increase in metabolic rate. The Harris and Benedict (HB) 1919 formula is the equation mainly used to calculate resting energy expenditure (cREE) compared with measured REE (mREE) by indirect calorimetry (IC), but other formulas are also applied in current practice.

The present study aimed to assess mREE in patients with ALS compared with 12 cREE formulas and study the relevant threshold of REE variation to screen patients with a higher evolving risk.Nutritional assessments and body composition (by bioimpedance analysis) were performed in patients with ALS.

mREE was measured by IC, and cREE was calculated using the HB 1919, HB 1984, World Schofield, De Lorenzo, Johnstone, Mifflin, World Health Organization/FoodandAgricultureOrganization, Owen, Fleisch, Wang, Rosenbaum, and Nelson formulas.

Functional and respiratory evolution and survival by log-rank test according to two thresholds of REE variation (10% and 20%) were studied.A total of 315 patients with ALS were included in the study. The median mREE was 1503 kcal/24 h (range, 1290-1698 kcal/24 h), which was higher than all predictive equations (P < 0.0001). Depending on the predictive equation, REE variation >10% and 20% was found in 35.2% to 76.3% and 14.6% to 53.3% of patients with ALS, respectively.

Patients with an REE variation >20% with HB 1919 and HB 1984 had a lower survival. Moreover, with this same threshold and the Mifflin formula, patients had higher functional and respiratory evolutions and lower survival.The increase in metabolic rate is present according to the different cREE formulas used compared with IC.

In clinical practice, REE formulas (e.g., HB 1919, HB 1984, or Mifflin) can be used as a reference value compared with IC to screen patients with ALS with an REE variation >20% and a higher evolving risk.

Compound FL0097
FL0097-5mg 5mg Ask for price
Description: Compound FL0097

Julabo FL1201 Chiller
BAT2504 EACH
EUR 8025.6

FL-411
HY-111102 25mg
EUR 1575.6

FL411
462472 25.0mg
EUR 450

FL-411
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Description: FL-411

FL-411
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FL-411
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FL104
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Description: FL104

FL104
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Description: FL104

FL104
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FL104
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Description: FL104

FL104
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FL118
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FL118
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(R)-FL-118
F401290 25mg
EUR 23000
Description: 151636-76-9

Julabo FL300 Chiller
BAT2500 EACH
EUR 4700.4

Julabo FL601 Chiller
BAT2502 EACH
EUR 6319.2

Human IL-37(1F7/F1L1ζ) ELISA kit
E22-HC116.48 48T
EUR 295

Human IL-37(1F7/F1L1ζ) ELISA kit
E22-HC116.96 96T
EUR 395

F630111L10Rik (Mouse) - 3 unique 27mer siRNA duplexes - 2 nmol each
SR401571 2 nmol Ask for price

Anti-ORF1 FL49 (4E11)
YF-MA19548 100 ug
EUR 435.6
Description: Mouse monoclonal to ORF1 FL49

Human IL-37/IL1F7/F1L1Z ELISA Kit
RK00117 96 Tests
EUR 625.2

Gilson PIPETMAN L Fixed F5000L 5000ul
FA10031 EACH
EUR 256.8

FL3
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N-Des(4-Fluorophenyl)-N-(3-fluorophenyl) Ezetimibe
D292325 100mg
EUR 227
Description: 1700622-06-5

4-Fluoro-delta-(4-fluorophenyl)benzenebutanol
F591810 2.5g
EUR 3000
Description: 50337-85-4

3-(3-Fluorobenzyl)-4-[(3-fluorobenzyl)oxy]benzaldehyde
F597935 10mg
EUR 345
Description: 1000370-24-0

3-(2-Fluorobenzyl)-4-[(2-fluorobenzyl)oxy]benzaldehyde
F597955 500mg
EUR 800
Description: 1000370-25-1

N-Des(4-Fluorophenyl)-N-(3-Fluorophenyl)-Ezetimibe-d4
D292327 50mg
EUR 7600

1-(4-Fluorophenyl)-N-[(4-fluorophenyl)methyl]methanimine
F632245 250mg
EUR 1200
Description: 428819-12-9

3-Des-(4-fluorophenyl) 3-(4-Fluorobiphen-3-yl) Aprepitant
D228795 75mg
EUR 12800

5-fluoro 203
C4114-10 10 mg
EUR 289.2
Description: 5-fluoro 203 (5F-203) is an antitumor agent and cytotoxic compound that acts as a potent AhR agonist [1][2][3]. The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor involved in regulating xenobiotic-metabolizing enzymes such as cytochrome P450.

5-fluoro 203
C4114-25 25 mg
EUR 582
Description: 5-fluoro 203 (5F-203) is an antitumor agent and cytotoxic compound that acts as a potent AhR agonist [1][2][3]. The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor involved in regulating xenobiotic-metabolizing enzymes such as cytochrome P450.

5-fluoro 203
C4114-5 5 mg
EUR 184.8
Description: 5-fluoro 203 (5F-203) is an antitumor agent and cytotoxic compound that acts as a potent AhR agonist [1][2][3]. The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor involved in regulating xenobiotic-metabolizing enzymes such as cytochrome P450.

5-fluoro 203
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Description: 5-fluoro 203

5-Fluoro-2-(4-fluorophenyl)-4-(trifluoromethyl)-1,3-oxazole
F601165 100mg
EUR 1200
Description: 83081-29-2

5-Fluoro ADB
F587245 10mg
EUR 158
Description: 1971007-89-2

4-Fluoro-5-(2-fluorophenyl)-1H-pyrrole-3-carboxaldehyde
F428220 500mg
EUR 800
Description: 928324-57-6

(S)-2-[[3-(3-Fluorobenzyl)-4-[(3-fluorobenzyl)oxy]benzyl]amino]propanamide
F590975 10mg
EUR 775
Description: 1000370-27-3

pCDNA3.1-FLAG(-)
PVT18203 2 ug
EUR 309.6

5-fluoro AMT HCl
463460 1.0mg
EUR 350

5-Fluoro NNEI
F588720 10mg
EUR 759
Description: 1445580-60-8

4-fluoro-N-(3-fluoro-4-methylphenyl)-3-{[(4-methoxyphenyl)methyl
T50103-10mg 10mg Ask for price
Description: 4-fluoro-N-(3-fluoro-4-methylphenyl)-3-{[(4-methoxyphenyl)methyl]sulfamoyl}benzamide

4-fluoro-N-(3-fluoro-4-methylphenyl)-3-{[(4-methoxyphenyl)methyl
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Description: 4-fluoro-N-(3-fluoro-4-methylphenyl)-3-{[(4-methoxyphenyl)methyl]sulfamoyl}benzamide

4-fluoro-N-(3-fluoro-4-methylphenyl)-3-{[(4-methoxyphenyl)methyl
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Description: 4-fluoro-N-(3-fluoro-4-methylphenyl)-3-{[(4-methoxyphenyl)methyl]sulfamoyl}benzamide

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Description: 4-fluoro-N-(3-fluoro-4-methylphenyl)-3-{[(4-methoxyphenyl)methyl]sulfamoyl}benzamide

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Description: 4-fluoro-N-(3-fluoro-4-methylphenyl)-3-{[(4-methoxyphenyl)methyl]sulfamoyl}benzamide

9-Fluorenol 95%
F01640 5G
EUR 106.51

5-Fluoro-UTP
NU-1115L 5 x 10µl
EUR 461.7

5-Fluoro-UTP
NU-1115S 10µl
EUR 157.6

2-Fluoro-ATP
NU-145L 5 x 10µl
EUR 604.6

2-Fluoro-ATP
NU-145S 10µl
EUR 208.5

5-Fluoro-UMP
NU-146L 5 x 50µl
EUR 439.5

5-Fluoro-UMP
NU-146S 50µl
EUR 150.1

9-FLUORENOL
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5-Fluoro-AMB
F587305 100mg
EUR 1800
Description: 1801552-03-3

4F2LC Antibody
39274-100ul 100ul
EUR 468

Decane, 1-fluoro-
581786 1.0g
EUR 310

9-Fluorenone
F01650 25G
EUR 126.48

5-Fluoro-dUMP
NU-153L 5 x 50µl
EUR 439.5

5-Fluoro-dUMP
NU-153S 50µl
EUR 150.1

5-Fluoro-dUTP
NU-154L 5 x 20µl
EUR 478.9

5-Fluoro-dUTP
NU-154S 20µl
EUR 150.1

Decane, 1-fluoro-
T21116-10mg 10mg Ask for price
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Decane, 1-fluoro-
T21116-1g 1g Ask for price
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Decane, 1-fluoro-
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9-Fluorenone
F462780 250g
EUR 173
Description: 486-25-9

5-Fluoro ADBICA
F587255 100mg
EUR 4500
Description: 1801338-27-1

5-Fluoro Isatin
F592000 10g
EUR 58

5-Fluoro Uracil
F596000 100g
EUR 138
Description: 51-21-8

5-Fluoro SDB-005
F596270 25mg
EUR 1200

(4-Fluoro-1-naphthalenyl)[1-(5-fluoropentyl)-1H-indol-3-yl]methanone
F594460 50mg
EUR 1800
Description: 1391485-39-4

pCDNA3.1-FLAG-TR4
PVT14611 2 ug
EUR 594

τ-Fluvalinate
T35419-10mg 10mg Ask for price
Description: τ-Fluvalinate

τ-Fluvalinate
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Description: τ-Fluvalinate

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2-Fluoro Viminol
F468230 100mg
EUR 3000
Description: 63880-43-3

4-Fluoro U-47931E
F479310 500mg
EUR 800
Description: 67579-18-4

5-Fluoroindan
F588415 1g
EUR 800
Description: 37530-82-8

5-Fluoro Uridine
F596500 100mg
EUR 126
Description: 316-46-1

Pyrazine, 2-fluoro-
20-abx182629
  • EUR 978.00
  • EUR 326.40
  • EUR 410.40
  • 100 g
  • 10 g
  • 25 g

4-Fluoroindole
20-abx183597
  • EUR 393.60
  • EUR 309.60
  • 10 g
  • 5 g

5-Fluorouracil
20-abx183733
  • EUR 376.80
  • EUR 276.00
  • EUR 226.80
  • 100 g
  • 25 g
  • 5 g

2-Fluorophenol
20-abx185738
  • EUR 292.80
  • EUR 243.60
  • EUR 493.20
  • EUR 226.80
  • 100 g
  • 25 g
  • 500 g
  • 5 g

5-Fluorouracil
B1519-1G each
EUR 130.8

5-Fluorouracil
B1519-5G each
EUR 248.4

5-Fluorouracil
FD0080 5g
EUR 75.66

5-Fluorouracil
F034-1G 1 g
EUR 67.2

5-Fluorouracil
F034-5G 5 g
EUR 115.2

5-Fluoroindole
GK0555-1G 1 g
EUR 64.8

4-Fluorophenol
GK2089-25G 25 g
EUR 57.6

5-Fluoroisatin
GK4345-25G 25 g
EUR 132

5-Fluoroisatin
GK4345-5G 5 g
EUR 74.4

7-Fluoroisatin
GX5733-5G 5 g
EUR 103.2

5-Fluorouracil
HY-90006 1g
EUR 142.8

5-Fluorouracil
GP6168-100G 100 g
EUR 250.8

5-Fluorouracil
GP6168-25G 25 g
EUR 122.4

5-Fluorouracil
GP6168-5G 5 g
EUR 64.8

pCDNA3.1-FLAG-PSPH
PVT14713 2 ug
EUR 594

5-Fluorouracil
16220-01 1G
EUR 22.4

5-Fluorouracil
16220-14 5G
EUR 33.6

3'-(6-Fluorescein) CPG *1000 Ã…*
6014-1g 1 g
EUR 446
Description: There are several ways of labeling an oligonucleotide with fluorescein.

5-Fluorouracil
GP6168-100 100
EUR 177.9

5-Fluorouracil
GP6168-25 25
EUR 71.1

5-Fluorouracil
GP6168-5 5
EUR 23.8

5-Fluoroindole
GK0555-1 1
EUR 23.8

4-Fluorophenol
GK2089-25 25
EUR 18.2

5-Fluoroisatin
GK4345-25 25
EUR 79.1

5-Fluoroisatin
GK4345-5 5
EUR 31.7

1-Fluorobutane 98%
F02790 10G
EUR 968.15

1-Fluorodecane 95%
F03040 1G
EUR 191.31

1-Fluorohexane 99%
F03210 1G
EUR 146.97

5-Fluoroindole
F03220 1G
EUR 194

5-Fluorouracil 98%
F04860 25G
EUR 162.6

2-Fluoro-ara-ATP
NU-10703-10 10µmol
EUR 540.1

7-Fluoroisatin
GX5733-5 5
EUR 55.4

2-Fluorophenol
S-2050 1ML
EUR 224.4

5-Fluorouracil
40690008-1 5 g
EUR 114.99

5-Fluorouracil
40690008-2 10 g
EUR 181.65

5-Fluorouracil
40690008-3 25 g
EUR 317.71

5-Fluorouracil
40690008-4 1 g
EUR 43.81

5-Fluorouracil
T0984-10mg 10mg Ask for price
Description: 5-Fluorouracil

5-Fluorouracil
T0984-1g 1g Ask for price
Description: 5-Fluorouracil

5-Fluorouracil
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Description: 5-Fluorouracil

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Description: 5-Fluorouracil

5-Fluorouracil
T0984-5mg 5mg Ask for price
Description: 5-Fluorouracil

One Health refers to the collaborative efforts of multiple disciplines working locally, nationally and globally to attain optimal health for people, animals and our environment.

The One Health approach is increasingly popular in the context of growing threats from emerging zoonoses, antimicrobial resistance and climate change.

The Food and Agriculture Organization of the United Nations, World Organisation for Animal Health and World Health Organization have been working together in the wake of the avian influenza crisis in the Asia-Pacific region to provide strong leadership to endorse the One Health concept and promote interagency and intersectoral collaboration.

The programme on highly pathogenic emerging diseases in Asia (2009-2014) led to the establishment of a regional tripartite coordination mechanism in the Asia-Pacific region to support collaboration between the animal and human health sectors. The remit of this mechanism has expanded to include other priority One Health challenges, such as antimicrobial resistance and food safety.

The mechanism has helped to organize eight Asia-Pacific workshops on multisectoral collaboration for the prevention and control of zoonoses since 2010, facilitating advocacy and operationalization of One Health at regional and country levels.

The tripartite group and international partners have developed several One Health tools, which are useful for operationalization of One Health at the country level. Member States are encouraged to develop a One Health strategic framework taking into account the country’s context and priorities.